Prof Dr Eike Nagel
Prof. Nagel has a longstanding history of research, teaching and training in cardiovascular magnetic resonance. He has established and translated several CMR application and imaging techniques into clinical practice.  He has published over 500 imaging-related publications and has authored several clinical guidelines, e.g. on standardized image acquisition, standardized reporting and standardized quantification for cardiovascular magnetic resonance. He is one of the founding members and Past President of the Society for Cardiovascular Magnetic Resonance (SCMR). He leads the Institute for Experimental and Translational Cardiovascular Imaging and DZHK Centre for Cardiovascular Imaging in Frankfurt in his role as DZHK Professor (dzhk.de/forschung/dzhk-professuren/). In his clinical position he leads the Interdisciplinary Cardiovascular Imaging Service and Consultant Cardiologist in the Departments of Cardiology and Radiology at the University Hospital Frankfurt am Main, offering a state-of-the art clinical service and clinical translation of research findings into clinical routine. 

Speed and Standardization

Prof Nagel has been leading various Task Forces and performed multiple studies to standardize and harmonize CMR examinations to generate accurate, reproducible and clinical meaningful data with minimal effort and time. The overall goal is to improve healthcare by developing diagnostic tools which optimize patient pathways.

CMR in HFpEF

Prof Nagel is developing and validating novel  imaging parameters based on CMR for the characterization and classification of patients with heart failure with preserved ejection fraction (HFpEF). A better understanding of the underlying pathophysiology may lead to better treatment opportunities and benefit to an increasingly large group of patients.
In a study funded by the German Centre for Cardiovascular Research (DZHK) Prof Nagel will validate these novel techniques versus invasive pressure-volume loops as well as echocardiography.

Ischaemic Heart Disease

Prof Nagel has established new methods for assessment of the presence of myocardial ischaemia by MRI, including stress myocardial perfusion using adenosine and dobutamine, as well as wall motion abnormality imaging by dobutamine (DSMR). He has assessed the accuracy of these techniques and demonstrated their clinical efficacy. He is conducting a multicentre clinical trial, MR-Inform, which is testing whether ischaemia imaging by adenosine stress perfusion can guide clinical management, in a head-to-head comparison with the invasive measurements of fractional flow reserve. MR-Inform is substantially supported by National Institute for Health Research (NIHR), UK  and  Bayer Healthcare, Germany.
10 most cited publications:
Coronary magnetic resonance angiography for the detection of coronary stenoses
WY Kim, PG Danias, M Stuber, SD Flamm, S Plein, E Nagel, SE Langerak, ...
New England Journal of Medicine 2001:345 (26), 1863-1869 - full text

Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI comparison with dobutamine stress echocardiography
E Nagel, HB Lehmkuhl, W Bocksch, C Klein, U Vogel, E Frantz, A Ellmer, ...
Circulation 1999:99 (6), 763-770​ - full text

Noninvasive detection of myocardial ischemia from perfusion reserve based on cardiovascular magnetic resonance
N Al-Saadi, E Nagel, M Gross, A Bornstedt, B Schnackenburg, C Klein, ...
Circulation 2000:101 (12), 1379-1383 - full text

Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease
E Nagel, C Klein, I Paetsch, S Hettwer, B Schnackenburg, K Wegscheider, ...
Circulation 2003:108 (4), 432-437 - full text

Prognostic value of cardiac magnetic resonance stress tests adenosine stress perfusion and dobutamine stress wall motion imaging
C Jahnke, E Nagel, R Gebker, T Kokocinski, S Kelle, R Manka, E Fleck, ...
Circulation 2007:115 (13), 1769-1776 - full text

Standardized cardiovascular magnetic resonance imaging (CMR) protocols, society for cardiovascular magnetic resonance: board of trustees task force on standardized protocols
CM Kramer, J Barkhausen, SD Flamm, RJ Kim, E Nagel
J Cardiovasc Magn Reson 2008:10, 35 - full text (updated 2013 - full text)

Alterations in the local myocardial motion pattern in patients suffering from pressure overload due to aortic stenosis
M Stuber, MB Scheidegger, SE Fischer, E Nagel, F Steinemann, OM Hess, ...
Circulation 1999:100 (4), 361-368 - full text

Comparison of dobutamine stress magnetic resonance, adenosine stress magnetic resonance, and adenosine stress magnetic resonance perfusion
I Paetsch, C Jahnke, A Wahl, R Gebker, M Neuss, E Fleck, E Nagel
Circulation 2004:110 (7), 835-842 - full text

Magnetic resonance low-dose dobutamine test is superior to SCAR quantification for the prediction of functional recovery
E Wellnhofer, A Olariu, C Klein, M Gräfe, A Wahl, E Fleck, E Nagel
Circulation 2004:109 (18), 2172-2174 - full text

Magnetic resonance imaging analysis of right ventricular pressure-volume loops in vivo validation and clinical application in patients with pulmonary hypertension
T Kuehne, S Yilmaz, P Steendijk, P Moore, M Groenink, M Saaed, ...
Circulation 2004:110 (14), 2010-2016 - full text