Dr Rocio Hinojar and colleagues provided a proof-of-concept that myocardial T1 mapping may be instrumental in discrimination between HCM and hypertension. T1-mapping indices are significantly higher in HCM in comparison with hypertension also when controlling for LGE and similar magnitudes of LVWT. Native T1 was the strongest independent discriminator between these 2 conditions. We further show that a majority of gene positive subjects have raised native T1 in the absence of phenotypically expressed disease (G+P−). Our findings propose a novel systematic approach toward discrimination of common conditions presenting with overt or borderline hypertrophic phenotypes, potentially supporting differential treatment pathways, as well as a screening tool for subclinical cardiomyopathy in G+P− subjects.
Congratulations to Rocio and many thanks to all collaborators in the International T1 Multicentre CMR Study for their contribution and support.
Link to the paper
Paper in press
T1 Mapping in Discrimination of Hypertrophic Phenotypes: Hypertensive Heart Disease and Hypertrophic Cardiomyopathy Findings From the International T1 Multicenter Cardiovascular Magnetic Resonance Study
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Prof Dr Eike Nagel
Director of the Institute for Experimental and Translational Cardiovascular Imaging, University Hospital Frankfurt