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We summarise the recent advances in non-invasive imaging, and bridge the novel insights into pathophysiology with future posibilities in diagnosis and manangement of SID patients. We propose an interdisciplinary framework to screening of cardiac involvement in SID using an indepth phenotyping of evolution of cardiovascular disease, to decipher the opportunities to improve patients’ cardiac care.
Link to the paper. Lupus myocarditis is likely more common than recognised clinically due to nonspecific symptoms and lack of reliable non-invasive diagnostic tests. We investigated the role of native T1 and T2 in recognition of active myocardial inflammatory involvement in patients with systemic lupus erythematous (SLE). We demonstrate that native T1 and T2 mapping support recognition of lupus myocarditis and reflect the response to anti-inflammatory treatment. Native T1 and T2 mapping may support an effective, noninvasive, radiation- and gadolinium contrast-free screening method for lupus myocarditis.
Link to the full text The DFG (Deutsche Forschungsgemeinschaft; German Research Council) has approved our grant application for a state-of-the art CT dedicated to cardiovascular research. With 50% support from the Federal State of Hesse this allows a 1.895.000 Euro investment into the Institute for Experimental and Translational Cardiovascular Imaging at the University Hospital Frankfurt (Goethe CVI). The CT will be run in close collaboration of Goethe CVi together with Radiology and Cardiology.
T1 mapping is a novel technique allowing to diagnose these diffuse conditions by measurement of T1 values, which directly correspond to variation in intrinsic myocardial tissue properties. In addition to providing clinically meaningful indices, T1-mapping measurements also allow for an estimation of extracellular space by calculation of extracellular volume fraction. Multiple lines of evidence suggest a central role for T1 mapping in detection of diffuse myocardial disease in early disease stages and complements late gadolinium enhancement in visualization of the regional changes in common advanced myocardial disease. As a quantifiable measure, it may allow grading of disease activity, monitoring progress, and guiding treatment, potentially as a fast contrast-free clinical application. Full paper...
The EACVI offers Research and Training Grants to help young experts in obtaining valuable experience and skills in a high standard academic centre in an ESC member country, other than their own. Research and training grants are available.
Deadline: September 30th 2016 Link to the application
Pro: Ready for prime time - Dr Valentina Puntmann, Frankfurt |
Prof Dr Eike NagelDirector of the Institute for Experimental and Translational Cardiovascular Imaging, University Hospital Frankfurt Archives
January 2021
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