Dr Rocio Hinojar and colleagues provided a proof-of-concept that myocardial T1 mapping may be instrumental in discrimination between HCM and hypertension. T1-mapping indices are significantly higher in HCM in comparison with hypertension also when controlling for LGE and similar magnitudes of LVWT. Native T1 was the strongest independent discriminator between these 2 conditions. We further show that a majority of gene positive subjects have raised native T1 in the absence of phenotypically expressed disease (G+P−). Our findings propose a novel systematic approach toward discrimination of common conditions presenting with overt or borderline hypertrophic phenotypes, potentially supporting differential treatment pathways, as well as a screening tool for subclinical cardiomyopathy in G+P− subjects.
Congratulations to Rocio and many thanks to all collaborators in the International T1 Multicentre CMR Study for their contribution and support.
Link to the paper